Pacemaker therapy, used for electrotherapy of bradycardia or heart failure, is a big market with a market size of over $15 billion.
Current pacemaker treatment uses a method of placing a lead on the apical right ventricle and applying electrical stimulation, which has a serious disadvantage of (1) heart failure due to a delay in ventricular electrical conduction (wide QRS) (2) tricuspid regurgitation (20-30%).
[Limits of Conventional Pacemaker Therapy]
To overcome these shortcomings, there are His bundle pacing (HBP) that provides electrical stimulation by placing a lead in His bundle, the electrical conduction system of the ventricle, or CRT that performs biventricular pacing by applying stimulation from two ventricles. However, both methods are not easy to apply because the procedure is not convenient and expensive (2~30 million won), and in the case of HBP there is a risk that the lead may be dropped out.
A technology developed by our company, has the advantage that it can directly act on the electrical conduction system of the heart as it can access a specific area of the heart (ventricular septum) with a simple minimally invasive procedure.
His pacing and pacing have a core common function in terms of directly transmitting electrical stimulation to the His bundle, the core axis of the heart conduction path, or the surrounding area.
|His Pacing||Cerclage Pacing|
|Final electrical stimulation target site||His bundle and adjacent tissues||His bundle and adjacent tissues|
|Approach path||Right atrium and right ventricle||Coronary sinus and ventricular septal veins|
|Applicable pacemaker leads||Only available with Medtronic's Select Secure 3830 lead||All leads of over the wire type can be used (Medtronic, Boston, St Jude, etc.)|
|Holds Relatively Rich Clinical Data||Holds Relatively Rich Clinical Data||Obtaining Initial Clinical Data|
|Relative comparative disadvantages||1. In 10-20% of patients, it is difficult to locate the lead by finding the appropriate point.
2. The high Pacing output causes shortening of the life of the pacemaker battery.
1. General surgeons need education on the procedure as a new approach to treatment
2. In addition to the pacemaker's general device tools, accessory devices necessary for the procedure are required (this is the company's development item) (this is the company's development item)
3. The procedure is affected by the septal vein structure.
|Clinical usefulness||Positioning as a new alternative to pacemaker and ventricular synchronization therapy||Provides wider treatment opportunities as an alternative to other approaches for His pacing|